Peptide Comparison Tables — Side-by-Side Guide

Peptide Comparison Tables — Side-by-Side

Quick reference comparisons to help you choose the right peptide for your research goals.

Weight Loss Peptides: Semaglutide vs Tirzepatide vs Retatrutide

Factor Semaglutide Tirzepatide Retatrutide
Type GLP-1 agonist Dual GLP-1 + GIP agonist Triple GLP-1 + GIP + Glucagon agonist
Mechanism Appetite suppression, slowed gastric emptying Appetite suppression + enhanced insulin Appetite suppression + insulin + active fat burning
Weight Loss (Clinical) 15-17% body weight 20-26% body weight Up to 24% (Phase 2 data)
Starting Dose 0.25mg weekly 2.5mg weekly 1mg weekly
Max Dose 2.4mg weekly 15mg weekly 12mg weekly
Titration Steps 0.25 → 0.5 → 1.0 → 1.7 → 2.4mg 2.5 → 5 → 7.5 → 10 → 12.5 → 15mg 1 → 2 → 4 → 8 → 12mg
GI Side Effects Moderate (nausea common) Often milder than semaglutide Moderate (more diarrhoea)
Maturity Most established, extensive data Well-studied, strong clinical data Investigational (Phase 2/3)
Onset 1-2 weeks for appetite effects 1-2 weeks 1-2 weeks
Cost/Month (Starter) ~£8 (0.25mg, 1 vial lasts months) ~£50 (2.5mg, 1 vial/month) ~£48 (1mg, 1 vial lasts 5 weeks)
Best For Budget-friendly, proven track record Maximum weight loss potential Body recomposition (fat burning + appetite)
Unique Advantage Most data, cheapest per dose Best clinical weight loss results Only triple agonist — burns fat actively

Which Should You Choose?

  • First timer on a budget? → Semaglutide. Most studied, cheapest, gentle titration.
  • Want the best results? → Tirzepatide. Clinical data shows superior weight loss.
  • Want fat burning, not just appetite suppression? → Retatrutide. Unique glucagon component.
  • Already tried semaglutide? → Tirzepatide or Retatrutide for potentially enhanced results.

Healing Peptides: BPC-157 vs TB-500

Factor BPC-157 TB-500
Type Gastric pentadecapeptide Thymosin Beta-4 fragment
Action Localized healing Systemic healing
Mechanism Angiogenesis, growth factor upregulation, anti-inflammatory Cell migration, actin upregulation, anti-inflammatory
Best Injection Site Near the injury (for targeted effect) Anywhere (works systemically)
Starting Dose 250mcg daily 500mcg daily
Max Dose 500mcg daily 1,500mcg daily
Cycle Length 4-8 weeks 4-8 weeks (loading + maintenance)
Loading Phase? No — consistent dose throughout Yes — higher initial dose recommended
Onset 1-2 weeks 2-3 weeks
Vial Size 5mg (£13.56) 5mg (£14.99)
Cost/Day (Starter) ~£0.68 ~£1.50
Best For Specific tendon/ligament, gut healing Multiple injuries, general recovery, post-surgery
Unique Advantage Gut healing (oral bioavailability in research) Systemic reach — heals everywhere
Stack Together? YES — the "Wolverine Stack" is the gold standard

Which Should You Choose?

  • Specific injury (one location)? → BPC-157. Inject near the injury.
  • Multiple injuries or general recovery? → TB-500. Works whole-body.
  • Gut issues? → BPC-157 (it's a gastric peptide — this is its origin).
  • Serious injury or post-surgery? → Both (Wolverine Stack). The combination is more effective than either alone.

Cognitive Peptides: Semax vs Selank

Factor Semax Selank
Type ACTH derivative nootropic Tuftsin derivative anxiolytic
Primary Effect Cognitive enhancement, focus Anxiety reduction, mood stability
Mechanism BDNF increase, dopamine/serotonin modulation GABA enhancement, serotonin modulation
Feel Sharper, more focused, mentally energised Calmer, less anxious, emotionally balanced
Routes SubQ or intranasal SubQ or intranasal
Starting Dose 200mcg daily 250mcg daily
Max Dose 600mcg daily 750mcg daily
Cycle 10-14 days on, equal time off 10-14 days on, equal time off
Onset 15-60 minutes 15-60 minutes
Cost/Day ~£0.80 ~£1.00
Best For Focus, learning, mental performance Anxiety, stress, emotional balance
Unique Advantage BDNF increase (neuroplasticity) Anxiolytic without sedation
Stack Together? YES — focus without anxiety

Which Should You Choose?

  • Need focus and mental energy? → Semax
  • Need anxiety relief and calm? → Selank
  • Want both? → Stack them (the Cognitive Stack). Best of both worlds.
  • Exam preparation? → Both combined for sharp, calm focus.

Growth Hormone Peptides: Full Comparison

Factor CJC-1295 + IPA Tesamorelin HGH 191AA MK-677 (Oral)
Type GHRH + GHS combo GHRH analogue Direct exogenous GH Oral GH secretagogue
Mechanism Stimulates GH pulse Stimulates GH release Provides GH directly Stimulates GH via ghrelin
GH Source Natural (your pituitary) Natural (your pituitary) External Natural (your pituitary)
Route SubQ injection SubQ injection SubQ injection Oral capsule
Dosing Daily before bed Daily before bed Daily (1-2x) Daily oral
Suppresses Natural GH? No No YES No
Primary Benefit Balanced GH elevation Visceral fat reduction Maximum GH effects Convenience (oral)
Sleep Improvement Excellent Good Good Moderate
Fat Loss Moderate Excellent (FDA-approved) Excellent Moderate
Muscle Building Moderate Moderate Strong Moderate
Side Effects Mild (water retention, tingling) Mild (injection site, joint) More (water retention, carpal tunnel, insulin) Increased appetite, water retention
Cost/Month ~£24-48 ~£240+ ~£300+ N/A (not stocked)
Best For Anti-aging, sleep, general GH benefits Targeted visceral fat loss Maximum body recomposition Those avoiding injections
Beginner Friendly? Yes ✅ Moderate No — start with peptides first Moderate

Which Should You Choose?

  • Beginner to GH peptides? → CJC-1295 + Ipamorelin. Safest, most cost-effective, preserves natural GH.
  • Want visceral fat loss specifically? → Tesamorelin. FDA-approved for this purpose.
  • Want maximum GH effects and understand the commitment? → HGH 191AA.
  • Budget-conscious? → CJC-1295 + Ipamorelin. Best value by far.

Quick Cost Comparison (Monthly at Starter Doses)

Peptide Monthly Cost Daily Cost Doses/Vial Best Value?
BPC-157 ~£20 £0.68 20 ⭐ Excellent
TB-500 ~£45 £1.50 10 Good
Semaglutide ~£8 £0.27 (weekly dose) 20 ⭐ Excellent
Tirzepatide ~£50 £1.79 (weekly dose) 4 Moderate
CJC-1295 + IPA ~£24 £0.80 50 each ⭐ Excellent
Semax + Selank ~£12 (per cycle) £1.60 20-25 each ⭐ Excellent
GHK-Cu ~£15 £0.50 50 ⭐ Best Value
NAD+ ~£90 £3.00 10 Moderate
PT-141 Per use: £2-4 As needed 5-10 Good
Tesamorelin ~£240 £8.00 5 Premium
HGH 191AA ~£300+ £10.00+ 5 Premium

⚠️ All prices are approximate and based on current peptideshopuk.co.uk pricing. Costs may vary. This guide is for research and educational purposes only. Peptide Shop UK sells peptides strictly for research use.