Semax + Selank — Complete Course Guide

Overview

Semax

• Synthetic peptide derived from ACTH (adrenocorticotropic hormone) fragment 4-10, with added Pro-Gly-Pro sequence
• Developed in Russia, approved there for clinical use since the 1990s
• Primary research applications: cognitive enhancement, neuroprotection, BDNF increase, focus, memory, stroke recovery
• Mechanism: Increases Brain-Derived Neurotrophic Factor (BDNF), modulates dopamine and serotonin, enhances neuroplasticity
• Nootropic (cognitive enhancer) — think of it as focus and mental performance peptide

Selank

• Synthetic peptide derived from tuftsin (an immunomodulatory peptide), with added Pro-Gly-Pro stability sequence
• Also developed in Russia, clinically approved there
• Primary research applications: anxiety reduction, mood stabilisation, cognitive support, immune modulation
• Mechanism: Enhances GABA system (calming), modulates serotonin, reduces anxiety without sedation, immune-supporting
• Anxiolytic (anxiety reducer) — think of it as calm focus and emotional balance peptide

Why Combine Them

• Semax = accelerator (focus, BDNF, mental energy, cognitive drive)
• Selank = stabiliser (anxiety reduction, emotional balance, calm clarity)
• Together = sharp focus WITHOUT the anxiety, enhanced learning with emotional stability
• They target different neurotransmitter systems, so they complement rather than compete

Administration Routes

Both can be administered:

1. Intranasal (most popular): Fastest onset (5-15 minutes), shorter duration (3-4 hours). Spray or drops into nose.
2. Subcutaneous (SubQ): Slower onset (30-60 minutes), longer duration (6-8 hours). Standard injection.

For intranasal use, you'll need nasal spray bottles (available from pharmacies). Reconstitute as normal, then transfer to nasal spray bottle.

Starter Course

Semax

• Dose: 200mcg per administration
• Frequency: 1-2 times daily (morning, optionally early afternoon)
• Duration: 10-14 days (SHORT cycles — this is not a peptide you run for months)
• Reconstitution: 5mg + 2mL BAC water = 2,500mcg/mL
• SubQ units: 200mcg ÷ 2,500 = 0.08mL = 8 units (100u syringe)
• Intranasal: ~2 sprays per nostril (calibrated spray bottle)

Selank

• Dose: 250mcg per administration
• Frequency: 1-2 times daily
• Duration: 10-14 days
• Reconstitution: 5mg + 2mL BAC water = 2,500mcg/mL
• SubQ units: 250mcg ÷ 2,500 = 0.1mL = 10 units (100u)

Combined Starter

• Week 1: Enhanced focus and reduced background anxiety. Mental clarity improving. Subtle but noticeable.

• Week 2: Peak cognitive effects. Learning capacity enhanced. Emotional stability improved.

• End of cycle: Take equal time off (10-14 days) before next cycle.

• Doses per vial (each): 5,000mcg ÷ 200-250mcg = 20-25 doses

• Cost per day: ~£0.80 each × 2 = ~£1.60/day combined

• Vials for one cycle: 1 vial of each (with doses remaining for next cycle)

Intermediate Course

Semax: 400mcg, 1-2× daily (16 units per dose)

Selank: 500mcg, 1-2× daily (20 units per dose)

• Duration: 10-14 days on, equal off
• When to move up: After 1-2 starter cycles, wanting stronger cognitive effects
• Doses per vial: 12-13 per peptide
• Cost per day: ~£3.00 combined

Advanced Course

Semax: 600mcg, 2× daily (24 units per dose)

Selank: 750mcg, 2× daily (30 units per dose)

• Duration: 10-14 days strictly
• For: High-demand periods (exams, deadlines, critical work sprints)
• Stacking: Can add CJC-1295+Ipamorelin (before bed) for GH-mediated brain recovery
• Cycling is ESSENTIAL at this dose — do not exceed 14 days without a break

Critical: Cycling Protocol

Unlike most peptides, Semax and Selank require SHORT cycles:

Why short cycles? Both peptides modulate neurotransmitter systems. Extended use can lead to receptor adaptation, diminishing returns, and potential rebound effects when stopping. The short cycle preserves effectiveness.

Reconstitution

• Both: 5mg + 2mL BAC water = 2,500mcg/mL
• Both dissolve easily, clear solution
• For intranasal: Reconstitute as normal, then use a clean syringe to transfer measured amount to nasal spray bottle
• Label carefully — both look identical once reconstituted
• Refrigerate, use within 28 days

Dose Reference Table

Side Effects & Safety

Semax

Common: Mild headache (first 1-2 days), slight nasal irritation (intranasal), increased appetite Less Common: Overstimulation/restlessness (reduce dose), insomnia (don't dose after 3pm), irritability When to Stop: Persistent headache, significant mood changes, insomnia

Selank

Common: Mild drowsiness initially (adjusts within days), nasal irritation (intranasal), mild fatigue Less Common: Vivid dreams, slight dizziness, emotional sensitivity When to Stop: Excessive sedation, persistent fatigue, mood instability

Contraindications (Both)

• Bipolar disorder or severe mood disorders (both modulate neurotransmitters)
• Pregnancy/breastfeeding
• Currently on psychiatric medications (SSRIs, benzodiazepines) — consult healthcare provider
• Active seizure disorders

Supplies Needed

• Syringes: 0.3mL (30 unit) for best precision
• Nasal spray bottles (if using intranasal — available from pharmacies)
• BAC water: 10mL vial
• Alcohol swabs, sharps bin
• Vials: 1 of each per cycle (may last 2 cycles at starter dose)

Best Use Cases

Ready to Start?

• Shop Semax →
• Shop Selank →
• View the Cognitive Stack →
• Use Our Dosage Calculator →

⚠️ Disclaimer: This guide is for research and educational purposes only. Peptide Shop UK sells peptides strictly for research use. This content does not constitute medical advice. Always consult with a qualified healthcare professional before beginning any research protocol.